Dopamine

Dopamine is a catecholamine neurotransmitter which is a chemical released by inwardness kiosks to send suggests to other never cells, and plays an important role some(prenominal) central and peripheral nervous system. It helps control the brain to stick to hunting expedition and emotional responses. Dopamine is made within dopamine neurons in the upper brainstem in the substantia Nigra. The site of movement of dopamine transmission affects atomic number 18 shown in the fig. 1. This is the dopamine driveway: L-Tyrosine ? L-DOPA ? Dopamine ? Norepinephrine ? epinephrine Levodopa is converted to dopamine by the work on of the enzyme dopa-decarboxylase in the brain Dopamine is stored in and remains in axon terminals and released when the neuron is depolarised Dopamine interacts with specific membrane receptors to build up its effects, uses five known types of dopamine receptors, these receptors be labeled D1, D2, D3, D4, and D5 and they are G protein-coupled receptor s. Receptor effects terminated by re-uptake into the presynaptic neuron by a dopamine conveyor or by metabolic inactivation by monoamine oxidase B (MAO-B) or catechol-0-methyltransferase (COMT) Upon tax deduction, dopamine is transported from the cell into synaptic vesicles by the vesicular monoamine conveyer 2 (VMAT2).

Dopamine is stored in and remains in these vesicles until an action at law potential occurs and forces them to merge with the cell membrane via a process known as exocytosis, thereby dumping dopamine into synapses. at once in the synapse, dopamine binds to and activates postsynaptic dopamin e receptors, resulting in the signal of the ! presynaptic cell being propagated to the postsynaptic neuron. Dopamine also binds to presynaptic dopamine receptors, which heap both excite the presynaptic cell or inhibit it depending on their galvanizing potential. Presynaptic receptors with an inhibitory potential are called autoreceptors and inhibit neurotransmitter synthesis and release. They swear out to keep dopamine levels normalized in certain...If you emergency to get a full essay, order it on our website: OrderCustomPaper.com

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